Spatial consistency of neural firing regulates long-range local field potential synchronization: a computational study.

Abstract

Local field potentials (LFPs) are thought to integrate neuronal processes within the range of a few millimeters of radius, which corresponds to the scale of multiple columns. In this study, the model of LFP in the visual cortex proposed by Mazzoni et al. (2008) was adapted to organize a network of two cortical areas, in which pyramidal neurons were divided into two sub-population modeling columns with spatially organized connections to neurons in other areas. Using the model enabled the relationship between neural firing and LFP to be evaluated, in addition to the LFP coherence between the two areas. Results showed that: (1) neurons in a particular sub-population generated the LFP in the area; (2) the spatial consistency of neural firing in the two areas was strongly correlated with LFP coherence; and (3) this consistency was capable of regulating LFP coherence in a lower frequency band, which was originally introduced to neurons in a particular sub-population. These results were derived from a winner-take-all operation in the columnar structure; thus, they are expected to be common in the cortex. It is suggested that the spatial consistency of neural firing is essential for regulating long-range LFP synchronization, which would facilitate neuronal integration processes over multiple cortical areas.