Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25100062.
- Also identified by DOI 10.1016/j.cmet.2014.07.014 and PMC identifier 4159757.
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Abstract
The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc's regulation of cell physiology.
Medical subject headings
- Acetylglucosamine