A new activity for SAMHD1 in HIV restriction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25100520.
- Also identified by DOI 10.1038/nm.3657.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested.
Medical subject headings
- HIV Infections
- HIV-1
- Monomeric GTP-Binding Proteins
- RNA, Viral
- Virus Replication