Seeking help: B cells adapting to flu variability.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25101885.
- Also identified by DOI 10.1126/scitranslmed.3008409.
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Abstract
The study of influenza vaccines has revealed potential interactions between preexisting immunological memory and antigenic context and/or adjuvantation. In the face of antigenic diversity, the process of generating B cell adaptability is driven by cross-reactive CD4 memory cells, such as T follicular helper cells from previous infections or vaccinations. Although such "helped" B cells are capable of adapting to variant antigens, lack of CD4 help could lead to a suboptimal antibody response. Collectively, this indicates an interplay between CD4 T cells, adjuvant, and B cell adaptability.
Medical subject headings
- Adaptation, Physiological
- B-Lymphocytes
- Influenza, Human