Out of the F-box: reawakening the pancreas.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25105572.
- Also identified by DOI 10.1016/j.stem.2014.07.006 and PMC identifier 4172310.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The adult pancreas lacks stem cells, and consequently, differentiation of pancreatic endocrine cells has been restricted to embryonic development or experimental manipulation. In this issue of Cell Stem Cell, Sancho et al. (2014) show that pancreas-specific loss of the ubiquitin ligase Fbxw7 stabilizes an endocrine-specific transcription factor, Ngn3, thus inducing in vivo β cell neogenesis.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- F-Box Proteins
- Glucagon-Secreting Cells
- Insulin-Secreting Cells
- Nerve Tissue Proteins
- Somatostatin-Secreting Cells
- Ubiquitin-Protein Ligases