The tailless root of glioma: cancer stem cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25105574.
- Also identified by DOI 10.1016/j.stem.2014.07.004 and PMC identifier 4239656.
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Abstract
In this issue of Cell Stem Cell, Zhu et al. (2014) demonstrate that a genetically engineered glioma model displays a functional cellular hierarchy defined by expression of the nuclear orphan receptor Tlx. Targeting cancer stem cells through genetic deletion of TLX promotes cancer stem cell death and differentiation and extends survival.
Medical subject headings
- Brain Neoplasms
- Glioma
- Neoplastic Stem Cells