Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25105576.
- Also identified by DOI 10.1016/j.stem.2014.07.010.
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Abstract
Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.
Medical subject headings
- Breast Neoplasms
- Cell Adhesion Molecules
- Cell Proliferation
- Cell Transformation, Neoplastic
- Mammary Glands, Animal
- Membrane Proteins
- Neoplastic Stem Cells
- Nuclear Proteins