Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible Enterococcus faecium harboring LiaSR substitutions.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 25107294.
- Also identified by DOI 10.1093/cid/ciu642 and PMC identifier 4271039.
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Abstract
High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 µg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations >2 µg/mL.
Medical subject headings
- Anti-Bacterial Agents
- Bacteremia
- Daptomycin
- Enterococcus faecium
- Gram-Positive Bacterial Infections