Pleiotropic functions for transcription factor zscan10.
basic_science · Level V
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- Record sourced from PubMed, PMID 25111779.
- Also identified by DOI 10.1371/journal.pone.0104568 and PMC identifier 4128777.
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Abstract
The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof.
Medical subject headings
- Genetic Pleiotropy
- Transcription Factors