Localized GABAergic inhibition of dendritic Ca(2+) signalling.
review · Level V
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- Record sourced from PubMed, PMID 25116141.
- Also identified by DOI 10.1038/nrn3803 and PMC identifier 4383162.
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Abstract
Neuronal circuits are defined by synaptic connections between their cellular constituents. In this article, I highlight several recent studies emphasizing the surprising level of precision exhibited by inhibitory GABAergic synapses within the neocortex and hippocampus. Specifically, GABAergic inputs to dendritic shafts and spines of pyramidal cells have a key role in the localized regulation of neuronal Ca(2+) signalling. These findings provide important new insights into the cellular mechanisms underlying the contributions of inhibitory transmission to both normal and abnormal brain activity.
Medical subject headings
- Calcium
- Calcium Signaling
- Dendrites
- GABAergic Neurons
- Neural Inhibition