In vivo prediction of tuberculosis-associated cavity formation in rabbits.
basic_science · Level V
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- Record sourced from PubMed, PMID 25117755.
- Also identified by DOI 10.1093/infdis/jiu449 and PMC identifier 4296171.
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Abstract
The presence of cavitary lesions in patients with tuberculosis poses a significant clinical concern due to the risk of infectivity and the risk of antibiotic treatment failure. We describe 2 algorithms that use noninvasive positron emission tomography (PET) and computed tomography (CT) to predict the development of cavitary lesions in rabbits. Analysis of the PET region of interest predicted cavitary disease with 100% sensitivity and 76% specificity, and analysis of the CT region of interest predicted cavitary disease with 83.3% sensitivity and 76.9% specificity. Our results show that restricting our analysis to regions with high [(18)F]-fluorodeoxyglucose uptake provided the best combination of sensitivity and specificity.
Medical subject headings
- Dental Pulp Cavity
- Tooth Diseases
- Tuberculosis