Genotype-phenotype correlation--promiscuity in the era of next-generation sequencing.

Lu, James T; Campeau, Philippe M; Lee, Brendan H · N Engl J Med · 2014

review · Level V

Where this comes from

Abstract

Newly cost-effective next-generation sequencing has led to an explosion of discoveries of novel genetic mutations that reveal the rampant "promiscuity" of genotype-phenotype relationships. Such discoveries should ultimately revolutionize clinical care.

Medical subject headings