CHK it out! Blocking WEE kinase routs TP53 mutant cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25125257.
- Also identified by DOI 10.1158/1078-0432.CCR-14-0720 and PMC identifier 4860818.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.
Medical subject headings
- Carcinoma, Squamous Cell
- Cell Cycle Proteins
- Head and Neck Neoplasms
- Nuclear Proteins
- Protein Kinase Inhibitors
- Protein Kinases
- Protein-Tyrosine Kinases
- RNA, Small Interfering
- Tumor Suppressor Protein p53