A timeless but timely connection between replication and recombination.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25126777.
- Also identified by DOI 10.1016/j.cell.2014.07.029.
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Abstract
Initiation of meiotic recombination by DNA double-strand break formation is temporally coordinated with replication. Murakami and Keeney show that this coordination requires recruitment of the Dbf4-dependent kinase to the replication fork by the conserved TIM-TIPIN complex. The same mechanism may regulate other important replication-associated processes.
Medical subject headings
- Cell Cycle Proteins
- DNA Breaks, Double-Stranded
- DNA Replication
- Meiosis
- Protein Serine-Threonine Kinases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins