Three-dimensional flash flow microreactor for scale-up production of monodisperse PEG-PLGA nanoparticles.

Min, Kyoung-Ik; Im, Do Jin; Lee, Hyune-Jea; Kim, Dong-Pyo · Lab Chip · 2014

basic_science · Level V

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Abstract

We present a pressure-tolerant 3D parallel polyimide (PI) film microreactor operating at up to ~160 bars with direct 3D flow focusing geometry for mass production of PEG-PLGA nanoparticles in a ~10(1) gram-scale (g h(-1)).

Medical subject headings