Hormone whodunit: clues for solving the case of intratumor androgen production.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25135482.
- Also identified by DOI 10.1158/1078-0432.CCR-14-1188 and PMC identifier 4216738.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
One of the key mechanisms by which prostate cancer cells evade hormone therapy is through intratumor testosterone production. New evidence points toward androstenedione as a potential precursor of intratumor androgen production and furthers nomination of AKR1C3 as a therapeutic target in advanced disease.
Medical subject headings
- Androgens
- Androstenedione
- Prostatic Neoplasms