Matching wits with melanoma brain metastases: from biology to therapeutics.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25135484.
- Also identified by DOI 10.1158/1078-0432.CCR-14-1121.
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Abstract
Melanoma brain metastases (MBM) present a significant clinical challenge. Molecular profiling of MBM is useful to identify molecular pathways, such as the PI3K pathway, that are specifically and differentially altered in MBM. Therapeutic studies should recruit patients with MBM and prospective tissue collection will lay the foundation for further advances.
Medical subject headings
- Brain Neoplasms
- Melanoma
- Neoplasm Metastasis
- Phosphatidylinositol 3-Kinases