Skeletal (stromal) stem cells: an update on intracellular signaling pathways controlling osteoblast differentiation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25138551.
- Also identified by DOI 10.1016/j.bone.2014.07.028.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.
Medical subject headings
- Bone and Bones
- Cell Differentiation
- Intracellular Space
- Osteoblasts
- Signal Transduction
- Stem Cells