Paracrine network: another step in the complexity of resistance to EGFR blockade?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25139340.
- Also identified by DOI 10.1158/1078-0432.CCR-14-1615.
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Abstract
Increased secretion of EGFR ligands amphiregulin and TGFα by limited KRAS-mutant clones is suggested as a paracrine resistance mechanism to anti-EGFR antibodies in colorectal cancer models. These findings are biologically sound but need to be replicated, including in the clinical setting, to foresee whether they are clinically relevant and therapeutically exploitable.
Medical subject headings
- Amphiregulin
- Colorectal Neoplasms
- Drug Resistance, Neoplasm
- ErbB Receptors
- Paracrine Communication
- Transforming Growth Factor alpha