diCal-IBD: demography-aware inference of identity-by-descent tracts in unrelated individuals.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25147361.
- Also identified by DOI 10.1093/bioinformatics/btu563 and PMC identifier 4296155.
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Abstract
We present a tool, diCal-IBD, for detecting identity-by-descent (IBD) tracts between pairs of genomic sequences. Our method builds on a recent demographic inference method based on the coalescent with recombination, and is able to incorporate demographic information as a prior. Simulation study shows that diCal-IBD has significantly higher recall and precision than that of existing single-nucleotide polymorphism-based IBD detection methods, while retaining reasonable accuracy for IBD tracts as small as 0.1 cM. http://sourceforge.net/projects/dical-ibd.
Medical subject headings
- Genomics
- Software