A multiplex panel of plasma markers of immunity and inflammation in classical kaposi sarcoma.
case_control · Level III
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- Record sourced from PubMed, PMID 25149762.
- Also identified by DOI 10.1093/infdis/jiu410 and PMC identifier 4334829.
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Abstract
Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we compared plasma from 15 human immunodeficiency virus (HIV)-negative classic KS cases to plasma from 29 matched controls, using a multiplex panel of immunity markers. Of 70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were strongly and significantly associated with KS, after adjustment for age and smoking status. These and previous observations are consistent with a tumor-promoting role for these cytokines, particularly CXCL10, but the small sample size and case-control design preclude firm conclusions on KS risk or pathogenesis. Larger, well-designed prospective studies are needed to better assess the association of these markers with KS.
Medical subject headings
- Biomarkers
- Inflammation
- Sarcoma, Kaposi