Break-up of two-dimensional MnO2 nanosheets promotes ultrasensitive pH-triggered theranostics of cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25156250.
- Also identified by DOI 10.1002/adma.201402572.
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Abstract
Chemically exfoliated two-dimensional MnO2 nanosheets are successfully modified with amino-polyethylene glycol as a theranostic platform for ultrasensitive stimuli-responsive theranostics of cancer. The highly dispersed MnO2 nanosheets exhibit a unique break-up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T1 -weighted magnetic resonance imaging. Such a pH-triggered breaking-up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH-responsive drug release and circumvent the multidrug resistance of cancer cells.
Medical subject headings
- Drug Carriers
- Magnetic Resonance Imaging
- Manganese Compounds
- Nanostructures
- Neoplasms
- Oxides