Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25156908.
- Also identified by DOI 10.1002/adhm.201400355 and PMC identifier 4339402.
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Abstract
Surface-modified poly(lactic-co-glycolic acid) (PLGA)/poly(β-aminoester)(PBAE)nanoparticles (NPs) have shown great promise in gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface-modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than traditional NPs composed of PLGA or PLGA/PBAE blends alone.
Medical subject headings
- Gene Transfer Techniques
- Lactic Acid
- Lung
- Nanoparticles
- Polyglycolic Acid