UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation.
basic_science · Level V
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- Record sourced from PubMed, PMID 25158899.
- Also identified by DOI 10.1038/ncomms5762.
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Abstract
Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.
Medical subject headings
- Chromosomal Proteins, Non-Histone
- DNA Helicases
- DNA-Binding Proteins
- Dosage Compensation, Genetic
- Drosophila Proteins
- Drosophila melanogaster
- RNA, Long Noncoding
- RNA-Binding Proteins
- Transcription Factors