Bromodomain inhibition in diffuse large B-cell lymphoma--giving MYC a brake.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25165099.
- Also identified by DOI 10.1158/1078-0432.CCR-14-1651.
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Abstract
Bromodomains are conserved protein regions that function as epigenetic readers by recognizing specific histone modifications. The common association of bromodomains with enhancer and super-enhancer regions in diffuse large B-cell lymphoma contributes to its pathogenesis. Bromodomain inhibition reduces tumor growth largely through the disruption of transcriptional networks driven by oncogenic MYC.
Medical subject headings
- Azepines
- Cell Proliferation
- Lymphoma, Large B-Cell, Diffuse
- Proto-Oncogene Proteins c-myc
- Triazoles