Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.
basic_science · Level V
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- Record sourced from PubMed, PMID 25165411.
- Also identified by DOI 10.1002/adma.200901718 and PMC identifier 4143259.
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Abstract
End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective.