Finding the missing link between the unfolded protein response and O-GlcNAcylation in the heart.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25170091.
- Also identified by DOI 10.1161/CIRCRESAHA.114.304855 and PMC identifier 4153403.
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Abstract
The ER stress-inducible transcription factor, x-box binding protein 1 (XBP1), which enhances protein glycosylation in the endoplasmic reticulum (ER), was shown to also enhance protein glycosylation outside the ER, via a process called O-GlcNAcylation, which protected the heart from ischemia/reperfusion damage.
Medical subject headings
- Biosynthetic Pathways
- DNA-Binding Proteins
- Hexosamines
- Transcription Factors
- Unfolded Protein Response