Sending mixed messages for cell population control.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25171399.
- Also identified by DOI 10.1016/j.cell.2014.08.013 and PMC identifier 4351990.
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Abstract
Cells often receive signals to proliferate, but how population density is controlled is unclear. Hart et al. now show that a single secreted molecule that instructs both proliferation and death in T cells establishes a bistable response: the population is driven to either extinction or to a homeostatically defined density.
Medical subject headings
- CD4-Positive T-Lymphocytes
- Interleukin-2
- Models, Biological
- Signal Transduction