Building a temperature-sensitive ion channel.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25171401.
- Also identified by DOI 10.1016/j.cell.2014.08.008.
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Abstract
The biophysical basis of temperature-sensitive ion channel gating has been a tough nut to crack. Chowdhury, et al. use a protein engineering approach to render a temperature-insensitive voltage-gated channel cold- or heat-responsive to reveal principles for temperature-gating and a plausible model for molecularly enabling this mode of environmental responsiveness.
Medical subject headings
- Ion Channels
- Protein Engineering