Cell-nonautonomous control of the UPR: mastering energy homeostasis.
Where this comes from
- Record sourced from PubMed, PMID 25185942.
- Also identified by DOI 10.1016/j.cmet.2014.07.009.
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Abstract
Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) in hypothalamic neurons are common features of obesity, resulting in leptin and insulin resistance. In this issue, Williams et al. (2014) demonstrate, for the first time, cell-nonautonomous UPR signaling between brain and liver in the context of glucoregulation.
Medical subject headings
- DNA-Binding Proteins
- Endoplasmic Reticulum Stress
- Energy Metabolism
- Glucose
- Neurons
- Pro-Opiomelanocortin
- Transcription Factors