Stem cell lineage specification: you become what you eat.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25185944.
- Also identified by DOI 10.1016/j.cmet.2014.08.006 and PMC identifier 4155325.
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Abstract
Nutrient availability and intermediate metabolism are increasingly recognized to govern stem cell behavior. Oburoglu et al. (2014) now demonstrate that glutamine- and glucose-dependent nucleotide synthesis segregate erythroid versus myeloid differentiation during hematopoietic stem cell specification, implicating a metabolism-centric regulation of lineage choices.
Medical subject headings
- Amino Acid Transport System ASC
- Cell Lineage
- Gene Expression Regulation
- Glucose
- Glutamine
- Hematopoietic Stem Cells