Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 25187374.
- Also identified by DOI 10.2337/db14-0563 and PMC identifier 4274808.
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Abstract
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
Medical subject headings
- Asian People
- Blood Glucose
- Genome-Wide Association Study