Fetal gender and several cytokines are associated with the number of fetal cells in maternal blood--an observational study.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 25188498.
- Also identified by DOI 10.1371/journal.pone.0106934 and PMC identifier PMC2923456.
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Abstract
OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood. METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification. RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood. CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.