Gene regulatory networks by transcription factors and microRNAs in breast cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25189779.
- Also identified by DOI 10.1093/bioinformatics/btu597.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Gene regulatory networks (GRNs) affect numerous cellular processes and every process of life, and abnormalities of GRN lead to breast cancer. Transcription factors (TFs) and microRNAs (miRNAs) are two of the best-studied gene regulatory mechanisms. However, the architecture and feature of GRNs by TFs and miRNAs in breast cancer and its subtypes were unknown. In this study, we investigated the GRNs by TFs and miRNAs with emphasis on breast cancer classifier genes at system level.
Medical subject headings
- Breast Neoplasms
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Gene Regulatory Networks
- MicroRNAs
- Transcription Factors