Comment on "Local impermeant anions establish the neuronal chloride concentration".
editorial · Level V
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- Record sourced from PubMed, PMID 25190787.
- Also identified by DOI 10.1126/science.1252978.
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Abstract
Glykys et al. (Reports, 7 February 2014, p. 670) conclude that, rather than ion transporters, "local impermeant anions establish the neuronal chloride concentration" and thereby determine "the magnitude and direction of GABAAR currents at individual synapses." If this were possible, perpetual ion-motion machines could be constructed. The authors' conclusions conflict with basic thermodynamic principles.
Medical subject headings
- Brain
- Chloride Channels
- Chlorides
- Neurons
- Receptors, GABA-A