Comment on "Local impermeant anions establish the neuronal chloride concentration".
editorial · Level V
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- Record sourced from PubMed, PMID 25190788.
- Also identified by DOI 10.1126/science.1255337.
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Abstract
Glykys et al. (Reports, 7 February 2014, p. 670) proposed that cytoplasmic impermeant anions and polyanionic extracellular matrix glycoproteins establish the local neuronal intracellular chloride concentration, [Cl(-)]i, and thereby the polarity of γ-aminobutyric acid type A (GABAA) receptor signaling. The experimental procedures and results in this study are insufficient to support these conclusions. Contradictory results previously published by these authors and other laboratories are not referred to.
Medical subject headings
- Brain
- Chloride Channels
- Chlorides
- Neurons
- Receptors, GABA-A