Quality control: H2A.X links to better iPSCs.
editorial · Level V
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- Record sourced from PubMed, PMID 25192458.
- Also identified by DOI 10.1016/j.stem.2014.08.011.
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Abstract
Incorporating induced pluripotent stem cell (iPSC) technology in regenerative medicine requires better methods for defining and obtaining high-quality lines. Two papers in this issue of Cell Stem Cell (Buganim et al., 2014; Wu et al., 2014) now show that H2A.X deposition can serve as a functional epigenetic marker for distinguishing the quality of iPSCs, thus providing insights for better reprogramming methods.