Rewiring the niche: sympathetic neuropathy drives malignant niche transformation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25192459.
- Also identified by DOI 10.1016/j.stem.2014.08.012.
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Abstract
In recent years, it has become increasingly evident that hematological malignancies can alter their microenvironment, but the therapeutic implications of these changes and potential targets have not been well characterized. Recent findings now describe how sympathetic neuropathy can drive malignant transformation of the hematopoietic stem cell niche in hematopoietic malignancies.
Medical subject headings
- Autonomic Nervous System Diseases
- Cell Transformation, Neoplastic
- Stem Cell Niche