Neuregulin-1 alleviates Charcot-Marie-Tooth disease in rats.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25198045.
- Also identified by DOI 10.1038/nm.3684.
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Abstract
Disrupted differentiation of Schwann cells contributes to axonal loss in a rat model of Charcot-Marie-Tooth 1A neuropathy. Early neuregulin-1 treatment promotes Schwann cell differentiation, preserves axons and restores nerve function in this model.
Medical subject headings
- Charcot-Marie-Tooth Disease
- Disease Models, Animal
- Neuregulin-1