Atypical transforming growth factor-β signaling in the hypothalamus is linked to diabetes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25198046.
- Also identified by DOI 10.1038/nm.3673.
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Abstract
Aging and a high-fat diet are predisposing factors for type 2 diabetes. A study in mice suggests that dietary fat and aging lead to atypical transforming growth factor-β1 signaling in the hypothalamus, which disturbs whole-body glucose regulation.
Medical subject headings
- Aging
- Diabetes Mellitus
- Obesity
- RNA
- Stress, Physiological
- Transforming Growth Factor beta