Inhibiting Janus kinases to treat alopecia areata.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25198048.
- Also identified by DOI 10.1038/nm.3685.
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Abstract
Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ⁺NKG2D⁺ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.
Medical subject headings
- Alopecia Areata
- Janus Kinases
- Protein Kinase Inhibitors
- T-Lymphocytes, Cytotoxic