Inflammation: IL-36 has proinflammatory effects in skin but not in joints.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25201385.
- Also identified by DOI 10.1038/nrrheum.2014.156.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Given the known involvement of IL-36 in psoriasis it might be surprising that the latest mouse models show that inhibiting IL-36 signalling does not alter the course of inflammatory arthritis. Can we now add IL-36 to the list of inflammatory mediators that are not viable DMARD targets?
Medical subject headings
- Arthritis, Experimental
- Interleukin-1
- Psoriasis
- Synovitis