Incidental detection of cancer predisposition gene copy number variations by array comparative genomic hybridization.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 25201531.
- Also identified by DOI 10.1016/j.jpeds.2014.07.042.
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Abstract
We describe 2 pediatric patients who presented to medical genetics clinic for evaluation and were incidentally found via array comparative genomic hybridization to have pathogenic copy number variations of cancer predisposition genes. We subsequently reviewed 3554 previous array comparative genomic hybridization results to estimate the frequency of similar incidental findings.
Medical subject headings
- Comparative Genomic Hybridization
- DNA Copy Number Variations
- Genetic Predisposition to Disease
- Neoplasms