Host-microbe interactions and spatial variation of cancer in the gut.
Where this comes from
- Record sourced from PubMed, PMID 25202783.
- Also identified by DOI 10.1038/nrc3765.
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Abstract
The small intestine has a greater cell mass than the colon, it is longer and with greater surface area and has a faster rate of epithelial turnover. At first, this might suggest that the small bowel epithelium could be at greater risk of the cumulative genetic errors that predispose to cancer. However, the incidence of cancer of the small bowel is more than tenfold lower than that of colorectal cancer.
Medical subject headings
- Colorectal Neoplasms
- Host-Pathogen Interactions