Activation of Cre recombinase alone can induce complete tumor regression.
basic_science · Level V
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- Record sourced from PubMed, PMID 25208064.
- Also identified by DOI 10.1371/journal.pone.0107589 and PMC identifier 4160265.
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Abstract
The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of primary lymphomas in p53-/- mice. Our findings illustrate that Cre activation alone can induce the regression of established tumors.
Medical subject headings
- Antineoplastic Agents, Hormonal
- Integrases
- Lymphoma
- Tamoxifen
- Tumor Suppressor Protein p53