Inhibition of angiogenesis by antioxidant micelles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25213436.
- Also identified by DOI 10.1002/adhm.201400249.
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Abstract
Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer.
Medical subject headings
- Angiogenesis Inhibitors
- Antioxidants
- Micelles
- Neovascularization, Pathologic