Ultrathin Coatings with Change in Reactivity over Time Enable Functional In Vitro Networks Of Insect Neurons.

Reska, Anna; Gasteier, Peter; Schulte, Petra; Moeller, Martin; Offenhäusser, Andreas; Groll, Juergen · Adv Mater · 2008

basic_science · Level V

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Abstract

It's just not cricket! A novel coating system that enables covalent attachment of biomolecules in a nonfouling environment without use of additional chemical crosslinkers is presented. Concanavalin A is patterned on the coatings to direct cell adhesion and growth of neurons from the cricket Gryllus bimaculatus and generate functional, patterned in vitro insect neuronal networks for the first time.