Confinement-Induced Enhancement of Antigen-Antibody Interactions within Binary Nanopatterns to Achieve Higher Efficiency of On-Chip Immunosensors.
basic_science · Level V
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- Record sourced from PubMed, PMID 25213907.
- Also identified by DOI 10.1002/adma.200702188.
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Abstract
By combining molecular self-assembly, nanosphere lithography and reactive ion etching, large-scale nanopatterns of antibodies are fabricated for direct application in state-of-the-art on-chip immunosensors. Using in-situ surface plasmon resonance, the patterns are studied in view of their antigen binding capacity, which shows an increase of up to 120% solely in the case of antibody confinement into the nanopatches by means of a nonfouling embedding matrix.