Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 25214510.
- Also identified by DOI 10.1093/cid/ciu682 and PMC identifier 4650775.
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Abstract
Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.
Medical subject headings
- Interleukin-7
- JC Virus
- Leukoencephalopathy, Progressive Multifocal
- Viral Vaccines