Distinctive tRNA repertoires in proliferating versus differentiating cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25215483.
- Also identified by DOI 10.1016/j.cell.2014.08.031.
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Abstract
Transfer RNAs (tRNAs) deliver amino acids to the ribosome during mRNA translation. Gingold et al. now provide evidence that alterations in the cellular tRNA repertoire are tightly coordinated with changes in mRNA expression. These changes in the tRNA repertoire dictate translational programs that distinguish differentiating from proliferating cells.
Medical subject headings
- Cell Differentiation
- Cell Proliferation
- Protein Biosynthesis
- RNA, Transfer